Cosyne 2008 Workshops
March 4, 2008
Snow Bird, Utah
Julie Haas
Spike-Timing Dependent Plasticity of Inhibitory Cortical Synapses
Recent research has described the spatial receptive fields of superficial EC principal neurons as forming a tessellating lattice. The EC is also implicated as a source for epileptic activity. For these reasons, we sought to explore the effects of dynamic inhibitory synapses in a variety of models, aiming to understand how plasticity of inhibitory synapses shapes the response of single cells and of a network or layer of neurons (below, right). We show that timing-dependent plasticity of inhibitory synapses is crucial for the self-regulation of propagated activity in a network, and is permissive of receptive field formation.
