Cosyne 2008 Workshops
March 4, 2008
Snow Bird, Utah
Claudia Clopath (with Wulfram Gerstner)
Voltage model of STDP leads to BCM and ABS
Spike-Timing-Dependent Plasticity (STDP) has been described by numerous models, either simple phenomenological and biophysical models based on calcium-calmodulin dynamics. A challenge for all modeling approaches is to describe not only on experiment but a broad set of experimental paradigms in a single framework. Here we present a model of STDP that is triggered by presynaptic spike arrival in combination with postsynaptic voltage and generalises an earlier model [1]. Action potentials of the postsynaptic neuron lead to voltage peaks, but subthreshold voltage gives also a contribution. This simple phenomenological model of STDP
- accounts for the frequency effects of STDP that Sjoestroem has measured [2]
- accounts for the triplet effects of STDP that Bi-lab has measured [3]
- accounts for a voltage dependence similar to Artola-Broecher-Singer (ABS) [4]
- accounts for Dudek-and-Bear experiments [5]
- and can be formally reduced to the Bienenstock-Cooper-Munro (BCM) model [6] if spiking is generated by Poisson processes.
References
- [1] Pfister and Gerstner, J. Neuroscience, 2006
- [2] Sjoetrom et al., Neuron, 2001
- [3] Wang et al., Nature Neuroscience 2005
- [4] Artola et al., Nature, 1990 and Ngezahaio et al., J. Neuroscience 2000
- [5] Dudek and Bear, J. Neuroscience, 1993
- [6] Bienenstock, Cooper, Munro, J. Neuroscience, 1982
